泰亚赛福 —— 工业设备集采平台
美国Molecular Devices Corporation（MDC）公司成立于1983年，位于美国高科技密集的加里佛尼亚州，是一家致力于为生命科学和药物研发工作者提供专业的、高精度、高通量、高性能的微孔板测读分析仪和液体操作系统的厂商。拥有该领域的上百项专利技术，系列产品已被广泛应用于药物筛选、分子生物学、免疫学、细胞学、生物化学、电生理学等多个领域，是微孔板测读分析领域的国际第一品牌。总部位于美国硅谷，在英国、德国、挪威、韩国和日本均设有分支机构。2005年美国分子仪器公司正式进驻中国。
2011/3/12 18:24:56 阅读：1228次
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Dedicated platform for the rapid quantitation of biopharmaceutical products or contaminates from bioreactor/fermenters, downstream processing or final product quality control(生物制品污染物残留检测）如疫苗中DNA残留量检测
The production of biopharmaceuticals, such as monoclonal antibodies, recombinant proteins, vaccines, and nucleic acids requires special techniques and quality control methods. Electrophoresis, chromatography, and immunochemical methods are commonly used together to monitor and optimize the biopharmaceutical manufacturing process. The Threshold® System is a dedicated platform for the rapid quantitation of biopharmaceutical products or contaminants from bioreactors/fermenters, downstream processing and final product quality control. The system is ideal for the quantitation of proteins, peptides and non-sequence specific total DNA.
The Threshold System measures a wide range of analytes such as host cell proteins, bovine contaminants (BSA, IgG, transferring and insulin), Protein A and G, and total DNA at low concentrations. To simplify assay development, all reagents are supplied in pre-packaged kits to label your antibodies or commercially available antibodies. To optimize the interaction between the antigen and antibody, binding occurs freely in solution where the molecules are maintained in their native conformation and antibodies retain 100% of their activity. Assay sensitivity for proteins and peptides is typically equal to or better than radioimmunassays and at least 10X better than ELISA assays. When measuring DNA, sensitivity as low as 2 pg can be achieved. Typically assays have a dynamic range of 2 logs or greater, so fewer sample dilutions are required for accurate quantitation. Assays are fast and are complete in as little as 90 seconds.
Optional Threshold Enterprise Software is available with a complete validation package and security tools that comply with GLP/GMP/FDA 21 CFR Part 11 requirements. The Threshold System's proven advantages of sensitivity, speed, reproducibility and reliability, as well as MDC's strong technical experience and support, have elevated this system to be the gold standard in the industry.
General Specifications
Threshold System
Threshold Auxillary Manifold
Computer Specifications
Intel Core 2 Duo E8400 6M Cache, 3.0 GHz, 1333 MHz FSB
Windows XP Pro O.S.
CD-ROM drive
2 GB RAM
160 GB SATA Hard Disk
Threshold Software controls the workstation and collects and analyzes data. It includes five standard curve fits to provide the highest accuracy when quantitating unknowns. A complete summary report detailing the results can be printed or exported for further analysis.
The optional Threshold Enterprise Software has a spike recovery report for analysis of the results within the software application, a complete validation package that allows current and future Threshold System users to comply with GLP/GMP/FDA 21 CFR Part 11 requirements. Threshold Enterprise Software includes the following security tools:
The Threshold System measures a wide range of analytes such as host cell proteins, bovine contaminants (BSA, IgG, transferring and insulin), Protein A and G, peptides and total DNA at low concentrations using an enzyme-linked immunoassay. Analytes are measured by incubating them with the appropriate antibody, binding protein or oligonucleotide probe which is labeled with streptavidin and conjugated to urease to form a complex. The sample mixture is then filtered through a biotinyylated membrane to actively capture and concentrate the analyte complex from the sample matrix. The filter is inserted into the Threshold reader and detection of the enzyme-labeled complex occurs in 90 sec by measuring the rate of enzyme turnover using a low noise silicon sensor.
Assay sensitivity for proteins is typically equal to or better than radioimmunassays and at least 10X better than ELISAs. For total DNA, assay sensitivity of 2 pg can be achieved. The Threshold software controls the instrument and collects and analyzes the data (to learn more: link to new HTML page referenced on the last page of this document). To simplify assay development, the following reagent kits are available to label your antibodies or commercially available antibodies,
Threshold's Immuno-Ligand Assay (ILA) measures a broad range of analytes such as, drugs, proteins, and micro-organisms for biopharmaceutical development and production. Samples can range from fermentation supernatants, samples from a purification process and other biochemical preparations, to serum or other bodily fluids.
The Threshold Total DNA Assay quantitatively measures picograms of single-stranded DNA. Unlike hybridization techniques which require DNA probes or primers with a specific nucleic acid sequence, Thresholds Total DNA assay measures DNA with broad sequence specificity.
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| 产品编号 | 产品名称 | 产品简介 | 产品价格 |
|---|---|---|---|
| ML-14477-00 | 生物制品污染物残留检测 | Dedicated platform for the rapid quantitation of biopharmaceutical products or contaminates from bioreactor/fermenters, downstream processing or final product quality control | 0￥ |
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